Results from the Survey of Antibiotic Resistance (SOAR) 2020-21 in Vietnam: data based on CLSI, EUCAST (dose-specific) and pharmacokinetic/pharmacodynamic (PK/PD) breakpoints.

ABSTRACT:

Objectives

Antibiotic susceptibility determination of Streptococcus pneumoniae and Haemophilus influenzae from community-acquired respiratory infections collected in 2020-21 from two hospitals in Ho Chi Minh City, Vietnam.

Methods

MICs were determined by CLSI broth microdilution; susceptibility was interpreted based on CLSI, EUCAST and pharmacokinetic/pharmacodynamic (PK/PD) breakpoints.

Results

A total of 144 S. pneumoniae and 191 H. influenzae isolates were collected. S. pneumoniae susceptibility to amoxicillin and amoxicillin/clavulanic acid (2:1) was 56.9% and 56.3% (CLSI), 29.2% and 25.7% (EUCAST high-dose) and 78.5% using high-dose amoxicillin (4 g/0.25 g/day, PK/PD). Susceptibility to ceftriaxone was 91.7% by EUCAST (high-dose) and 50.7% by CLSI or PK/PD. Pneum

SUBMITTER: Torumkuney D 

PROVIDER: S-EPMC12641131 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature