Daily Cigarette Abstinence and Smoking Rate With Varenicline: Relationships With Treatment, Craving, and Affect During the First Week of the Quit Attempt.

ABSTRACT:

Introduction

Dichotomized smoking abstinence (abstinent/smoking) is the standard outcome for clinical trials, but obscures smoking behavior change. Examining both smoking probability and smoking rate as outcomes may identify unique barriers to cessation (eg, craving, affect) among individuals who are receiving treatment but unable to quit.

Aims and methods

Two-part latent growth modeling examined daily smoking probability and smoking rate during the first week of the quit attempt using self-reported cigarettes per day. Smoking trajectories and the effect of 12 weeks of varenicline (vs. placebo), craving, negative affect (NA), and positive affect (PA) on these trajectories were examined among 828 adults in a randomized smoking cessation trial (NCT01314001).

Results

On

SUBMITTER: Tonkin SS 

PROVIDER: S-EPMC12641181 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature