Silicate biomaterials-based multicellular scaffolds with specific cellular spatial distribution for infarcted myocardium repair.

ABSTRACT: Constructing artificial myocardial tissue that matches the structure and function of natural myocardium is a promising approach for repairing infarcted myocardium and reconstructing cardiac function. In this study, a biomimetic myocardium scaffold based on bioactive bioinks containing strontium silicate was prepared by bioprinting the specific spatial distribution of cardiomyocytes and aortic endothelial cells. First, the spatial distribution pattern of cardiomyocytes and endothelial cells is regulated through coaxial/parallel multi-channel 3D bioprinting method. The spatial distribution of cells can significantly affect the repair function of multicellular scaffolds by stimulating genes related to pathological homeostasis regulation and intercellular interactions. Second, the multicellula

SUBMITTER: Qin C 

PROVIDER: S-EPMC12641195 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature