Novel thiophene-thiazole-Schiff base hybrids: design, synthesis, antimicrobial and antioxidant activity with ADMET prediction, molecular docking and dynamics study.

ABSTRACT: This study was aimed to synthesize new antimicrobial and antioxidant agents with increased biological efficacy due to increasing pathogenic resistance and oxidative stress. In this context, a series of thiazole-Schiff base derivatives (2a-k) were synthesized via a two-step synthetic route (Scheme 1). The structures of the synthesized compounds were characterized using analytical methods, including IR, ¹H NMR, and HRMS. As part of the dual biological potential of the synthesized derivatives, in vitro antimicrobial studies were performed using the agar disc diffusion method, where 2f, 2h, and 2k showed excellent activity against both Gram-positive and Gram-negative bacterial strains. However , compound 2f exhibited the most prominent antimicrobial activity, especiall

SUBMITTER: Khan SJ 

PROVIDER: S-EPMC12641212 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature