Intrathecal versus intravenous umbilical cord mesenchymal stem cells for ischemic stroke sequelae.

ABSTRACT:

Background

Stroke is a leading cause of death worldwide. Traditional treatments have limitations, stem cell therapy has potential for regeneration after ischemic stroke. This study evaluated the safety and efficacy of allogeneic umbilical cord-derived mesenchymal stem cell (UC-MSC) infusion via the intravenous (IV) and intrathecal (IT) routes for treating neurological sequelae after ischemic stroke.

Methods

This phase II randomized controlled trial involved 32 patients aged 40-75 years with neurological sequelae after ischemic stroke. The patients were randomly assigned into two groups: 16 received two IT UC-MSC infusions plus rehabilitation therapy, and 16 received two IV UC-MSC infusions plus rehabilitation therapy. Additionally, 16 matched controls, paired with the IT gro

SUBMITTER: Nguyen LT 

PROVIDER: S-EPMC12641229 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature