Temporal variation in circulating GDF15 over 24 h in healthy young males.

ABSTRACT: The functions of Growth Differentiation Factor 15 (GDF15) include actions on metabolism, cell survival, immune response, inflammation, and inhibition of food intake. Temporal variations in circulating GDF15 over 24 h have been reported in two small cohorts: one during fasted conditions and one during an overfeeding regimen. Here, 22 healthy young men were studied over 24 h in a controlled setting approximating normal daily life with blood sampling every third hour. Plasma GDF15 concentrations were analyzed using cosinor rhythmometry and one-way repeated measures ANOVA. In the full cohort, cosinor analysis did not show a statistically significant 24-h rhythm of GDF15 (p = 0.0944), but the ANOVA revealed a significant modest effect of time on plasma GDF15 concentrations (p < 0.001). Explorat

SUBMITTER: Zilstorff DB 

PROVIDER: S-EPMC12641278 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature