Risk factors and diagnostic indicators for congenital syphilis: a Nationwide retrospective survey.

ABSTRACT: This nationwide retrospective study in Japan aimed to identify risk factors and diagnostic indicators for congenital syphilis (CS) and improve diagnostic accuracy. Data were collected from 230 pregnant women diagnosed with syphilis and their infants between 2015 and 2024. Of these, 49 infants were diagnosed with definite or highly probable CS, while 73 infants with excluded CS served as the control group. Multivariable logistic regression analysis revealed two significant risk factors for CS: maternal treatment not completed more than 4 weeks before delivery (odds ratio [OR]: 7.20; 95% confidence interval [CI]: 1.38-37.56; p = 0.02) and elevated total IgM levels in the infant (>20 mg/dL) (OR: 65.31; 95% CI: 4.53-941.39; p = 0.002). When using infant rapid plasma reagin (RPR) ≥1 as a diagno

SUBMITTER: Shimizu H 

PROVIDER: S-EPMC12641297 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature