Bottlebrush Polymer Templates for the Synthesis of Gold Nanostructures and their Applications as Photothermal Agents and SERS Substrates.

ABSTRACT: An innovative approach is presented for the synthesis of gold photothermal agents tailored for Near Infrared light NIR-I and NIR-II photothermal applications using bottlebrush polymers (BB) as soft templates (BB@Au). Upon exposure to NIR-I, (λ_ex = 808 nm) and NIR-II (λ_ex = 1064 nm) light, the photothermal agents (BB@Au) exhibit robust photothermal effects, achieving temperatures up to 58.3 °C under 500 mW cm^-2 NIR-II laser irradiation. This remarkable thermal response enables efficient eradication of cancer cells in both 2D and 3D settings. Furthermore, comprehensive studies demonstrate the biocompatibility of BB@Au, as evidenced by concentration-dependent and time-dependent analyses. Studies conducted with zebrafish larvae further confirm their safety, sho

SUBMITTER: Chauhan DS 

PROVIDER: S-EPMC12641368 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature