Reducing functional dysconnectivity in people with schizophrenia spectrum disorders.

ABSTRACT:

Background

The dysconnection hypothesis of schizophrenia posits that widespread synaptic inefficiencies lead to altered macroscale brain connectivity, contributing to symptom severity and cognitive deficits in individuals with schizophrenia spectrum disorders (SSD). Emerging evidence suggests that physical exercise may help to ameliorate these connectivity abnormalities and associated clinical impairments.

Aims

This study investigated whether reductions in functional dysconnectivity following exercise therapy were associated with clinical improvements in individuals with SSD. In addition, it explored the genetic underpinnings of these changes using imaging transcriptomics.

Method

Using data from the ESPRIT C3 trial, we analysed 23 SSD patients (seven female) undergoin

SUBMITTER: Wunderlich S 

PROVIDER: S-EPMC12641402 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature