FgNdk1 Promotes Effector Secretion to Scavenge ROS During Fusarium graminearum Infection.

ABSTRACT: Pathogens secrete numerous effectors to overcome plant-derived reactive oxygen species (ROS), but how pathogens modulate effector secretion during infection remains unclear. In this study, we showed that the nucleotide diphosphate kinase Ndk1 in Fusarium graminearum plays important roles in vegetative growth, conidiation, sexual reproduction and pathogenicity. The species-specific N-terminus and three active sites of FgNdk1 functioned in the development and virulence of F. graminearum and contributed to its enzymatic activity. Protein structure results showed that the N-terminus is rich in proline, and subcellular localisation and enzymatic activity assays confirmed that it was responsible for endoplasmic reticulum (ER)-anchoring; additionally, the proline-rich feature contributed to the r

SUBMITTER: Sun M 

PROVIDER: S-EPMC12641451 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature