Three-Dimensional Morphometric Analysis of Exfoliative Material Using Ultrahigh-Resolution OCT in Exfoliation Syndrome.

ABSTRACT:

Purpose

Exfoliation syndrome (XFS), characterized by the accumulation of fibrillar extracellular material in the anterior segment, is a leading cause of secondary glaucoma worldwide. This study aimed to characterize the three-dimensional morphology of exfoliative material on the anterior lens surface in XFS eyes using ultrahigh-resolution optical coherence tomography (UHR-OCT).

Methods

We imaged 17 eyes with lens photography and acquired volumetric UHR-OCT using radial scanning. We fine-tuned the Segment Anything Model to automatically identify the anterior lens capsule and surface. The exfoliative material was segmented and categorized as deposited (thickened epithelium layer), peeling-off, or detached, as well as central versus peripheral. Volumetric quantification of each

SUBMITTER: Win KY 

PROVIDER: S-EPMC12641458 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature