A study on drug delivery and release kinetics of polyethylene glycol-functionalized few-layer graphene (FLG) incorporated into a gelatin-chitosan bio-composite film.

ABSTRACT: This study develops a composite film by incorporating few-layer graphene (FLG) within a gelatin-chitosan polymer matrix for enhanced drug delivery. The FLG was functionalized in two steps to produce a secondary functionalized FLG (FLG-PEG), resulting in improved dispersion in water, as characterized using an optical microscope. Morphological analysis revealed that FLG-PEG nanosheets are well dispersed, resulting in a smoother, more uniform composite film with the polymer wrapping around them. The functionalized FLG was embedded in a polymeric matrix of chitosan and gelatin, and a bio-composite was prepared by solution casting. FTIR, TGA, and DSC analyses of the samples were conducted to confirm the successful functionalization of the FLG and the increased thermal stability of the composite

SUBMITTER: Sultana N 

PROVIDER: S-EPMC12641497 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature