Data-driven strategies for drug repurposing: insights, recommendations, and case studies.

ABSTRACT: Drug discovery is a complex, time-intensive, and costly process, often requiring more than a decade and substantial financial investment to bring a single therapeutic to market. Drug repurposing, the systematic identification of new indications for existing approved drugs, offers a cost-effective and expedited alternative to traditional pipelines, with the potential to address unmet clinical needs. In this study, we present a comparative analysis of drug-target interaction data from three extensively curated resources: ChEMBL, BindingDB, and GtoPdb, evaluating their release histories, curation methodologies, and coverage of approved and investigational compounds and targets. To facilitate therapeutic interpretation, we manually classified ChEMBL targets into 12 high-level biological famili

SUBMITTER: Savander S 

PROVIDER: S-EPMC12641610 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature