Exploring the Cardiovascular Impacts of Agmatine: A Systematic Review.

ABSTRACT:

Background

Agmatine (AG) is an endogenous neurotransmitter discovered in 1910. It acts on imidazoline I1 and I2 receptors, alpha-2 adrenoceptors, N-methyl-D-aspartate receptors (NMDAR), and serotonergic receptors and modulates nitric oxide synthase (NOS) subtypes. It has neuroprotective, anxiolytic, antidepressant, anticonvulsant, and anti-inflammatory properties and is involved in cognitive functions and withdrawal. The cardiovascular effects of AG began to be explored after the hypotensive effect of clonidine, an imidazoline agonist, was demonstrated. The current study aimed to systematize the effects of AG on the cardiovascular system obtained in previous preclinical studies.

Methods

We searched three databases, PubMed, Cochrane, and Embase, using the keywords "agmatine"

SUBMITTER: Manole OM 

PROVIDER: S-EPMC12641643 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature