Acylpyruvates and Their Heterocyclic Derivatives as Growth Regulators in <i>Chlorella vulgaris</i>.

ABSTRACT: Acylpyruvate derivatives represent a promising yet underexplored class of compounds for modulating microalgal growth and metabolism. Inspired by the metabolic role of pyruvate and the diverse bioactivity of its acylated analogs, this study investigates the structure-activity relationship of a diverse library of 55 acylpyruvate-derived compounds for stimulation of the green microalga Chlorella vulgaris. The library, encompassing 12 chemotypes including acylpyruvic acids, their esters, and various heterocyclic derivatives, was screened for effects on C. vulgaris growth. Six compounds were identified as active ones that enhanced biomass production in a preliminary microassay. Notably, four of these active compounds were direct acylpyruvate derivatives, highlighting this scaffold

SUBMITTER: Novokshonova AD 

PROVIDER: S-EPMC12641706 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature