Molecular Epidemiology of SARS-CoV-2 in Northern Greece from the Index Case up to Early 2025 Using Nanopore Sequencing.

ABSTRACT:

Background/objectives

Since its emergence in late 2019, SARS-CoV-2 has demonstrated remarkable genetic diversity driven by mutations and recombination events that shaped the course of the COVID-19 pandemic. Continuous genomic monitoring is essential to track viral evolution, assess the spread of variants of concern (VOCs), and inform public health strategies. The present study aimed to characterize the molecular epidemiology of SARS-CoV-2 in northern Greece from the first national case in February 2020 through early 2025.

Methods

A total of 66 respiratory samples collected from hospitalized patients across Northern Greece were subjected to whole-genome sequencing using Oxford Nanopore Technologies' MinION Mk1C platform and the ARTIC protocol. Sequences were analyzed with PAN

SUBMITTER: Meletis G 

PROVIDER: S-EPMC12641784 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature