Identification and Computational Analysis of <i>BRCA2</i> Variants in Mexican Women from Jalisco, Mexico, with Breast and Ovarian Cancer.

ABSTRACT:

Background

Breast and ovarian cancers (BC and OC) are prevalent malignancies in women globally, with germline variants in the BRCA2 gene significantly increasing the risk of developing these cancers. Despite extensive studies, the frequency and impact of BRCA2 variants in women from Jalisco, Mexico, remain underexplored.

Objective

The aim of this study was to identify and characterize BRCA2 gene variants in Mexican women diagnosed with BC and OC and to assess their functional and structural consequences using computational analyses.

Methodology

Genomic DNA from 140 Mexican women with BC and/or OC, selected based on clinical criteria suggestive of BRCA2 variants, was sequenced using NGS targeting BRCA2 coding regions. Functional effects were predic

SUBMITTER: Garcia-Verdin PM 

PROVIDER: S-EPMC12641962 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature