Potential drug targets for chronic obstructive pulmonary disease in the plasma proteome identified through Mendelian randomization.

ABSTRACT:

Background

Chronic obstructive pulmonary disease (COPD) is the third leading cause of death worldwide. Current options such as glucocorticoids and bronchodilators improve symptoms but carry risks, including infection and immunosuppression. To guide safer, mechanism-based therapies and biomarker discovery, we genetically prioritize circulating proteins.

Methods

We used the integrated dataset from Sun et al., which combined seven large-scale plasma proteome GWAS covering 4,853 proteins measured on SOMAscan, Olink, and xMAP platforms, to evaluate the causal effects of circulating proteins on COPD through two-sample Mendelian randomization (MR). Only genome-wide significant cis-pQTLs (P < 5 × 10⁻⁸) with F > 10 were retained after LD clumping. Discovery analysis was performed wit

SUBMITTER: Jia Q 

PROVIDER: S-EPMC12641967 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature