Identification of active anti-aging ingredients from asparagus cochinchinensis based on the spectrum-effect relationship.

ABSTRACT: Aging is an irreversible degenerative process marked by declining physiological function. Developing therapeutics to delay aging and prolong healthy life represents a significant research focus. The dried roots of Asparagus cochinchinensis (Lour.) Merr. (Asparagi Radix, AR), a traditional Chinese medicine, possesses various pharmacological properties, including antioxidative, antitumor, and anti-inflammatory effects, and is commonly used in anti-aging formulas. Although steroidal saponins are its major active components, the specific compounds responsible for its anti-aging effects remain unidentified, and their mechanistic basis is unclear. This study evaluated the anti-aging effects of AR-derived total saponin extracts (ATSE) in Caenorhabditis elegans and elucidated underlying mechanisms

SUBMITTER: Wan R 

PROVIDER: S-EPMC12642084 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature