Sustained drug-releasing hydrogel coatings for ureteral stents to prevent iatrogenic injury-induced ureteral stricture.

ABSTRACT: Iatrogenic injury-induced ureteral stricture often occurs during the treatment of ureteral disorders, and can lead to serious consequences requiring further medical care. The stricture prevention requires effective strategies to inhibit fibrosis, reduce oxidative stress and inflammatory responses during the insertion of ureteral stents. Here, we explore the anti-stricture effects of commercial ureteral stents modified with hydrogel coatings, which contain functionalized poly (lactic-co-glycolic acid) (fPLGA) nanoparticles (NPs) loaded with the drug of pirfenidone (PFD). The polyacrylamide (PAM) hydrogel coatings are robustly grafted onto the polyurethane (PU) stent using the surface initiated radical polymerization, while PFD-fPLGA NPs decorated with acryloyl functional groups were securel

SUBMITTER: Tian D 

PROVIDER: S-EPMC12642134 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature