Global transcriptional regulation by the CodY gene: identification of critical compounds that enhance oxidative stress resistance in Lactobacillus delbrueckii subsp. Bulgaricus.

ABSTRACT:

Background

CodY (Control of dppY) is a global transcriptional regulator of Streptococcus thermophilus (ST). In this study, we utilized a S. thermophilus codY gene deletion mutant strain to explore metabolites that may affect the oxidative-stress resistance of Lactobacillus delbrueckii subsp. bulgaricus. The context of this research is to understand the role of CodY in the interaction between S. thermophilus and L. delbrueckii, particularly focusing on the impact of CodY on the oxidative-stress resistance of L. delbrueckii.

Results

Firstly, the ST-1ΔcodY mutant strain was constructed by the knockout technique. We found that codY gene deletion significantly reduced the growth rate and resistance to oxidative stress of L. delbrueckii in co-culture, with a decrease in viable bac

SUBMITTER: Wang T 

PROVIDER: S-EPMC12642168 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature