Loss of TET2 activity limits the ability of vitamin C to activate DNA demethylation in human HAP1 cells.

ABSTRACT:

Background

The TET family of proteins-TET1, TET2, and TET3-are α-KG and Fe²⁺ dependent dioxygenases that play crucial roles in active DNA demethylation and the deposition of epigenetic marks such as 5-hydroxymethylcytosine, 5-formylcytosine, and 5-carboxycytosine. TET proteins can also oxidize thymine to 5-hydroxymethyluracil - a modification whose role is still poorly understood. TET proteins add a new layer of information in regulating gene expression, cellular development, and lineage specification. Dysregulation of TET activity is implicated in various cancers, especially in hematological malignancies, where TET2 loss-of-function mutations are prevalent. TET2's role in hematopoiesis is critical, as its knockdown skews progenitor differentiation toward the myeloid lin

SUBMITTER: Gawronski M 

PROVIDER: S-EPMC12642257 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature