SARS-CoV-2 reinfection in interstitial lung disease patients and its association with clinical deterioration: a two-year prospective cohort study.

ABSTRACT:

Background

The COVID-19 pandemic has raised concerns about respiratory sequelae, particularly in the patients with preexisting interstitial lung disease (ILD). This study aimed to evaluate the longitudinal impacts of SARS-CoV-2 reinfection on patients with preexisting ILD, focusing on differential outcomes between single and multiple infection episodes.

Methods

A prospective cohort study was conducted (December 2022-March 2023), enrolling 347 adults with preexisting ILD and confirmed COVID-19 infection. Follow-up assessments were performed at baseline, 6-, 12-, and 24-month intervals. Data included demographics, pulmonary function tests (PFTs), high-resolution computed tomography (HRCT) scores, and clinical outcomes. Composite deterioration endpoint incorporating acute exace

SUBMITTER: Wang Y 

PROVIDER: S-EPMC12642266 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature