Polyploid giant cancer cells (PGCC): short-term return to multicellularity.

ABSTRACT:

Background

Polyploidization is associated with progression of cancer, making cancer cells more dangerous. The common polyploid cancer cells constitute a considerable part of tumors (up to 56% in metastases). The giant polyploid cancer cells (PGCC), which appear under severe stress caused by treatment when the majority of cells die, present an enigmatic phenomenon both in fundamental and practical sense because they develop treatment resistance.

Results

Using transcriptome meta-analysis, we studied different types of polyploid cancer cells and found that in common polyploid cancer cells, the genes of unicellular (UC) origin and stemness are upregulated (compared to diploid cancer cells). At that, the upregulated UC genes show a higher local and global protein interactome cent

SUBMITTER: Vinogradov AE 

PROVIDER: S-EPMC12642267 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature