Evolution of pneumococcal serotype 19A in children in Bangladesh: insights from genomic analysis.

ABSTRACT:

Background

Invasive pneumococcal disease (IPD), caused by Streptococcus pneumoniae, remains a major global health concern, particularly for children. Among more than 100 pneumococcal serotypes, 19A is known for its multidrug resistance (MDR) and increased incidence following PCV7/PCV10 introduction in many countries. Bangladesh introduced PCV10 in 2015 considering the low burden of 19A in the country.

Methods

Utilizing our IPD surveillance from 2004 to 2023, we investigated the hospital incidence of serotype 19A before and after PCV10 introduction among < 5 years old children in Bangladesh. Whole-genome sequencing was done for 153 serotype 19A isolates from IPD, otitis media, carriage, and urine samples. We used phylogenetic and BEAST analyses to investigate population struc

SUBMITTER: Tanmoy AM 

PROVIDER: S-EPMC12642354 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature