Image-guided therapy of colorectal cancer using a zirconium coordinated nanosensitizer.

ABSTRACT: Sonodynamic therapy (SDT) has gained attention as a promising non-invasive cancer treatment strategy due to its localized effects and superior tissue penetration. SDT induces apoptosis and immunogenic cell death (ICD) via the generation of reactive oxygen species (ROS) upon ultrasound irradiation. However, tumor heterogeneity, the immunosuppressive tumor microenvironment, and the limited accumulation of sonosensitizers at the tumor site pose significant challenges to SDT's therapeutic efficacy. In this study, a tumor-targeting nanosonosensitizer, Zr-HMME-PEG-Linaclotide (HP-LNC), was designed by coordinating the sonosensitizer hematoporphyrin monomethyl ether (HMME) with zirconium (Zr) to form a Zr-HMME complex. Polyethylene glycol (PEG) was used to enhance the complex's water dispersity a

SUBMITTER: Yang S 

PROVIDER: S-EPMC12642373 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature