A conserved sRNA regulates mucin adhesion and gut colonization across the Enterococcaceae.

ABSTRACT: Enterococci, particularly E. faecalis, can survive in diverse settings within and outside human hosts. The capacity of E. faecalis to colonize these locations relies on its ability to adapt by altering gene expression in response to environmental exposures. One mechanism for quickly altering gene expression is through regulation by small noncoding RNAs (sRNAs); sRNAs can regulate one or many target genes and either up- or down-regulate transcript stability and protein expression. While many sRNAs have been predicted in E. faecalis, few have experimentally established target mRNAs or physiological functions. Here, we investigate the targets, function, and mechanism of Enterococcus sRNA 84. We found that sRNA 84 is conserved within the family Enterococcaceae, suggesting

SUBMITTER: Bowden S 

PROVIDER: S-EPMC12642391 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature