Enrichment of a CD4^-CD8^- NK-like cytotoxic Vδ1/3 T cell subset in tuberculosis disease.

ABSTRACT: Tuberculosis (TB), caused by Mycobacterium tuberculosis, remains a leading cause of global morbidity and mortality. Although gamma-delta (γδ) T cells have increasingly been suggested to contribute to the TB immune response, quantitative and qualitative differences in this immune cell compartment between healthy and TB diseased individuals are not well-characterized. In this study, we used single-cell RNA sequencing to provide a high-resolution characterization of CD4^-CD8^- γδ T cells in peripheral blood across healthy Mtb-non-sensitized, healthy Mtb-sensitized, and TB disease pre-/post-treatment cohorts. We found upregulation of an activated and cytotoxic gene signature in γδ T cells of TB disease compared to both healthy cohorts. Strikingly, these

SUBMITTER: Kearns K 

PROVIDER: S-EPMC12642414 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature