The inner membrane complex protein, IMC55, is dispensable for intra-erythrocytic development of <i>Plasmodium falciparum</i>.

ABSTRACT: Plasmodium falciparum, an obligate intracellular Apicomplexan parasite and the causative agent of malaria must reside and replicate within a host cell during the intra-erythrocytic stage. The parasite utilizes a specialized double-membraned organelle, called the inner membrane complex for schizont-stage segmentation and merozoite motility during subsequent re-invasion. In this study, we investigate the function of IMC55, a multi-transmembrane inner membrane complex protein, which we identified as a putative interacting partner of the P. falciparum ER-resident calcium binding protein, PfERC. We have previously shown that PfERC is essential for parasite egress and our data shows that PfERC may also function in parasite invasion into the RBC. The whole genome transposon mutagene

SUBMITTER: Vick GW 

PROVIDER: S-EPMC12642417 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature