Electrophysiological profiling of exocytosis during early-stage development of the zebrafish lateral line.

ABSTRACT: Hair cells of the zebrafish lateral line have proven to be a good model for studying hair cell function in a system that is easily genetically manipulated, rapidly develops and is experimentally accessible. However, characterization of potential developmental changes, and possible differences along lateral line position are lacking. Here, we used in vivo patch clamp to investigate the electrophysiological and exocytic properties of neuromast hair cells over early development across body location. Long depolarizations led to steady increases in membrane capacitance, presumably due to exocytosis of vesicles localized to ribbon synapses. The magnitude and kinetics of capacitance changes did not vary significantly across the L1 to L6 position of neuromasts along lateral line, but the ma

SUBMITTER: Wang J 

PROVIDER: S-EPMC12642438 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature