Stress granules and protein aggregates reveal intracellular resource competition.

ABSTRACT: Stress granules are biomolecular condensates that form in response to environmental stress and disassemble once normal conditions are restored. However, when disassembly fails, stress granules can persist and solidify. While stress granule solidification has been well documented, the cellular mechanisms underlying the transition from reversible to persistent stress granules remain unclear. Persistent stress granules can seed the formation of pathological aggregates, such as TDP-43 in amyotrophic lateral sclerosis^{1, 2}. Although amyloid and tau aggregates are hallmarks of Alzheimer's disease, a subset of patients also develop TDP-43 deposits, suggesting a possible role for stress granule solidification in Alzheimer's disease progression^3-5. Despite theoretical models ex

SUBMITTER: Buchholz HE 

PROVIDER: S-EPMC12642510 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature