Genomes from 117 vertebrate species reveal rapidly evolving segmental duplication landscapes.

ABSTRACT: Segmental duplications are major drivers of evolutionary innovation, yet their dynamics across vertebrates remain poorly understood. Here, we identify segmental duplications from long-read sequenced genomes of 117 vertebrates and the starfish, generating the largest multi-species dataset of its kind. We find that vertebrate genomes show a higher propensity for tandem duplications than for interspersed duplications. However, when focusing only on subtelomeric regions, avian and mammalian genomes show the opposite propensity toward interspersed duplications. We also observe that, across vertebrates, tandem duplications tend to be larger than interspersed duplications. Next, we construct a segmental duplication network for each species, and use network-derived properties to quantify the dupli

SUBMITTER: Aqil A 

PROVIDER: S-EPMC12642534 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature