Bat power-metabolic profiling of the Egyptian fruit bat <i>Rousettus aegyptiacus</i> reveals distinctive cardiac adaptations.

ABSTRACT:

Aim

The present study aimed to elucidate which pathways contribute to cardiometabolic adaptation in Egyptian fruit bats.

Methods

Utilising cardiac tissues from Egyptian fruit bats (Rousettus aegyptiacus) and C57BL/6J mice, we combined liquid chromatography-mass spectrometry metabolic profiling, non-targeted ¹H NMR spectroscopy, and in silico computational modelling using the genome-scale mammalian network CardioNet.

Main findings

Our analyses revealed that bat hearts exhibit a distinct metabolic profile characterised by depleted glycogen reserves and increased reliance on lipid oxidation to meet energy demands. Notably, bat hearts displayed elevated fluxes in oxidative phosphorylation, β-oxidation of long-chain fatty acids, and the Krebs cycle

SUBMITTER: Karlstaedt A 

PROVIDER: S-EPMC12642545 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature