Somatostatin Receptors Shape Insulin and Glucagon Output within the Pancreatic Islet through Direct and Paracrine Effects.

ABSTRACT:

Aims/hypothesis

Pancreatic delta cells secrete somatostatin (SST), which can inhibit both alpha and beta cells of the pancreatic islet. By controlling insulin and glucagon release, delta cells play an important role in maintaining nutrient homeostasis. However, the mechanism by which a single inhibitory hormone inhibits both alpha and beta cells, which are often considered as functional antagonists in the counterregulatory control of blood glucose, has been a physiological riddle. Here, we solve this riddle through assessment of the contributions of alpha and beta cell specific somatostatin receptors to cell intrinsic behaviors and hormone release.

Methods

Islets from mice constitutively expressing fluorescent sensors reporting on cyclic AMP and Ca²⁺ in both alpha

SUBMITTER: Hart RG 

PROVIDER: S-EPMC12642553 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature