A Challenge To The Assumption That Short- versus Long-Access Groups of Opioid Users Represent Distinct Phenotypes.

ABSTRACT:

Rationale

One of the current models for drug (opioid) user typology employs differential access conditions to categorize takers into short-access and long-access groups (ShA, LgA) with the rationale that these groups represent distinct opioid user phenotypes. However, with the idea that differential vulnerabilities to opioid effects are already present prior to experimenter assignment into these groups, it is unclear that these groups represent distinct opioid user types. To clarify this, we have developed a method that includes principal component analysis-gaussian mixtures model clustering of variables derived from a new CENTERED (Cumulative Experience-Normalized Time-Effect on Response as an Exponential Decay structure) model. The goal of this study was to utilize CENTERED clust

SUBMITTER: Giunta MA 

PROVIDER: S-EPMC12642573 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature