Niche partitioning by resource size in the gut microbiome.

ABSTRACT: Niche partitioning promotes diversity of the human gut microbiota. However, the molecular basis of resource specialization and niche separation in the gut remains poorly understood. Here we show that structural differences in glycan transporters drive members of the genus Bacteroides, common human gut commensals, to specialize on distinct chain lengths of the same fructan molecule. While species encoding canonical SusCD systems for glycan import -formed by a membrane-embedded barrel capped with a lipoprotein lid- specialized in long-chain fructans, species with smaller lidless transporters, not previously described in Bacteroides, specialized in short-chain fructans. Strikingly, we found that a ~140-amino acid domain in the SusC barrel is a structural feature that governs sub

SUBMITTER: Moreno-Gamez S 

PROVIDER: S-EPMC12642598 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature