Developmental exposure to a PFAS mixture impairs the anamnestic response to influenza A virus infection in mice.

ABSTRACT: Developmental exposure to per- and polyfluoroalkyl substances (PFAS) has been linked to reduced antibody responses to childhood vaccines, but the underlying mechanisms remain unclear. Antibody production relies on interactions between various immune cell types, and it is unknown which are affected by PFAS exposure during development. To investigate this in a human-health relevant system, an in vivo model was established to delineate effects of developmental exposure to a mixture of four PFAS commonly found in human serum: PFOA, PFOS, PFHxS, and PFNA. Pregnant mice consumed water containing these PFAS throughout gestation and lactation. PFAS were measured in both mothers and offspring, and an exposure that avoided overt health issues was selected. The immune response to influenza A virus (I

SUBMITTER: Post CM 

PROVIDER: S-EPMC12642599 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature