UCM-A86 is a selective positive allosteric modulator of GluN1/GluN3 NMDA receptors.

ABSTRACT: N-methyl-d-aspartate (NMDA) receptors are ionotropic glutamate receptors that mediate excitatory neurotransmission in the central nervous system (CNS) where they play critical roles in normal and pathological brain functions and neurodevelopment. While the glutamate/glycine-activated GluN2-containing NMDA receptors (GluN1/GluN2) have been extensively studied, the physiological roles and pharmacology of glycine-activated GluN3-containing receptors (GluN1/GluN3) remain less understood. Although GluN1/GluN3 receptors exhibit unique functional properties and play distinct roles in neuronal development and synapse maturation, studies of their precise roles in neurophysiology and circuit function are impeded by limited availability of GluN3-selective pharmacological tools. This study desc

SUBMITTER: Benton AJ 

PROVIDER: S-EPMC12642611 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature