Interferon signaling promotes early neutrophil recruitment after zebrafish heart injury.

ABSTRACT: Heart injury triggers a robust cellular response in zebrafish, characterized by neovascularization, immune cell activation, and the infiltration of proliferative cardiomyocytes that collectively lead to scarless regeneration. Upon injury, damage-associated molecular patterns are released by dying cells and injured extracellular matrix. These molecules bind to pattern recognition receptors on various cell types, promoting inflammation and immune cell recruitment by upregulating chemokines and pro-inflammatory cytokines. We previously identified the activation of injury-induced interferon signaling as a distinguishing feature between the regenerative zebrafish and non-regenerative medaka. Here, we establish interferon-Φ1 (IFN 1) as the primary driver of interferon signaling after zebrafish h

SUBMITTER: Schmid AV 

PROVIDER: S-EPMC12642619 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature