Live longitudinal imaging of meningeal cerebrovascular injury and its sequelae in adult zebrafish.

ABSTRACT: Nearly 1.4 million people in the United States sustain a traumatic brain injury (TBI) each year, with almost half of those hospitalized for TBI developing long-term disability. For many patients, prolonged bleeding and inflammation from damaged vessels in the meninges result in longlasting sequelae. Although their injured blood vessels regrow, the site of injury is full of inflammatory immune cells that may influence vascular function. Adult zebrafish have a thin, translucent skull and a mammalian-like meninges that is easily imaged in living animals. We have established a novel adult zebrafish model to investigate vessel-immune cell interactions after meningeal cerebrovascular injury (mCVI). We use carefully calibrated sonication to rupture meningeal blood vessels without breaching the sk

SUBMITTER: Kraus A 

PROVIDER: S-EPMC12642638 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature