Variable Schwann cell merlin inactivation is targetable with TEAD1 inhibition in schwannomas.

ABSTRACT: Schwann cell tumors occur frequently in association with the vestibular nerves, leading to sensorineural hearing loss, and brainstem compression. In humans, unilateral vestibular schwannomas (VS) occur sporadically (VS^spo)¹, or bilaterally with neurofibromatosis type 2 syndrome (NF2) - VS^nf2.² VS formation is driven by sub-haploid NF2 gene dosage³, typically by biallelic loss.^4,5 Loss of merlin promotes hippo/TEAD dependent transcriptional reprogramming, proliferation, and paracrine signaling that varies across time, and tumor volume.^4,6 These variations lead to a clinically unpredictable course, and incomplete response to treatment. We hypothesized that Schwann cell merlin inactivation state determines cel

SUBMITTER: Laws MT 

PROVIDER: S-EPMC12642662 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature