Trends in Prenatal Opioid Use Disorder in California, 2010-2022.

ABSTRACT:

Introduction

Opioid-related deaths among perinatal populations have increased sharply in the U.S. Whether the recent ascendance of illicit fentanyl and other synthetic opioids in the drug supply translates to an increase in prenatal opioid use disorder remains unknown. This study investigated whether California's comparatively late fentanyl influx, in 2019, was associated with a subsequent increase in opioid use disorder among pregnant people.

Methods

This ecologic, repeated retrospective cohort study examined annual cohorts of individuals with an index live-birth delivery in California from 2010 to 2022. Analyses used statewide, all-payer linked hospitalization and emergency department records. Overall and subgroup-specific trends in the prevalence of prenatal opioid use di

SUBMITTER: Goldman-Mellor S 

PROVIDER: S-EPMC12642814 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature