Relationship between long-term outcomes and optimal time interval in patients with bilateral synchronous multiple primary lung cancers: a multi-institutional cohort study.

ABSTRACT:

Background

With the advancement of diagnostic technology and changes in living environment, the incidence of synchronous multiple primary lung cancer (sMPLC) is increasing. This study aims to investigate the impact of surgical timing on clinical outcomes.

Methods

This multi-institutional cohort study retrospectively enrolled 901 patients with bilateral sMPLC who underwent two surgeries from January 2017 to December 2022. Three different subgroups were determined based on the time interval between the 1^st surgery and the 2^nd surgery: Group-I (time interval ≤ 90 days), Group-II (90 days < time interval ≤ 180 days) and Group-III (time interval > 180 days).

Results

For the entire cohort, the median follow-up time from the second surgery was 49.2 mont

SUBMITTER: Guo W 

PROVIDER: S-EPMC12642896 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature