Ni-promoted reductive cyclization cascade enables a total synthesis of (+)-aglacin B.

ABSTRACT: The total synthesis of bioactive (+)-aglacin B was achieved. The key steps include an asymmetric conjugate addition reaction induced by a chiral auxiliary and a nickel-promoted reductive tandem cyclization of the elaborated β-bromo acetal, which led to the efficient construction of the aryltetralin[2,3-c]furan skeleton embedded in this natural product.

SUBMITTER: Yao SC 

PROVIDER: S-EPMC12642946 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature