On the physiological processes underlying optoretinography [Invited].

ABSTRACT: Optoretinography (ORG) is a label-free imaging of the light-evoked changes in the retina associated with alterations in the cell shape and refractive indices. Its most precise version, the phase-resolved optical coherence tomography (pOCT), exhibited sensitivity of about 10 nm in vivo, limited by the signal-to-noise ratio and accuracy of the tissue registration. While it is yet insufficient for the detection of single action potentials, which are about 1 nm in amplitude, it enables monitoring slower and larger deformations in other retinal layers. In response to a single flash delivered to the dark-adapted retina, photoreceptor outer segments (OS) exhibit rapid (millisecond-scale) contraction, reaching tens of nm in cones and hundreds of nm in rods. This effect can be explained by c

SUBMITTER: Li H 

PROVIDER: S-EPMC12642991 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature