High-resolution three-dimensional quantitative photoacoustic and ultrasound imaging of subcutaneous microvasculature in extremities.

ABSTRACT: Visualizing and monitoring morphological and functional information of microvasculature, including arterioles and venules, plays a crucial role in assessing vascular-related diseases. Clinical angiography methods have limitations in observing small peripheral microvessels down to 100 μm. Here, this study achieved three-dimensional (3D) non-invasive imaging of the subcutaneous microvascular network and monitored hemodynamic change by using an ultrasound (US)/photoacoustic (PA) dual-modality imaging system. Not only were the microvasculature and subcutaneous tissues in the extremities visualized with high resolution, but also the quantitative oxygen saturation (sO₂) of microvessels was measured. To monitor the hemodynamic change in microvasculature, vascular occlusion was performe

SUBMITTER: Long X 

PROVIDER: S-EPMC12642999 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature