The multidrug and toxin extrusion (MATE) transporter DTX51 antagonizes non-cell-autonomous HLS1-AMP1 signaling in a region-specific manner.

ABSTRACT: Multidrug and toxin extrusion (MATE) transporters are widely conserved across all domains of life and play diverse roles in plant development. Here, we investigated the role of DETOXIFICATION 51 (DTX51), a MATE transporter in Arabidopsis. Overexpression of DTX51 led to pleiotropic phenotypes resembling those of hls1 hlh1 and amp1 lamp1 loss-of-function mutants, which have disruptions of key developmental regulators that act non-cell-autonomously. Genetic and gene expression analyses revealed that DTX51 and HLS1 act within the same genetic pathway, forming a negative feedback loop at the transcriptional level. Spatially restricted overexpression experiments showed that, in contrast to HLS1 and AMP1, DTX51 acts in a region-specific manner within the shoot apical meristem, suggesting that DTX

SUBMITTER: Nobusawa T 

PROVIDER: S-EPMC12643059 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature