Anti-Mullerian hormone induces a reversible quiescence-associated secretory phenotype in preantral follicles†.

ABSTRACT: Anti-Müllerian hormone is a factor secreted by granulosa cells of growing follicles that regulates many aspects of ovarian function, including primordial follicle activation and early follicle development through inhibitory feedback. Treatment with exogenous anti-Müllerian hormone at supraphysiological levels can inhibit follicular development and prevent ovulation in mice, rats, and cats. Single-cell transcriptomic analysis of ovaries from mice treated postnatally with anti-Müllerian hormone identified a distinct quiescence signature in granulosa cells. Herein, we further characterized the anti-Müllerian hormone -induced quiescent cell state and drew parallels to developmental senescence by describing a reversible "quiescence-associated secretory phenotype." This state was characterized b

SUBMITTER: Meinsohn MC 

PROVIDER: S-EPMC12643070 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature