Preparation of polysaccharide composite films using cyclodextrin-conjugated chitosan for sustained release of hydrophobic drugs.

ABSTRACT: Cyclodextrin-conjugated polysaccharides are often used as functional materials for biological applications, such as drug carriers, because the hydrophobic cavity of the cyclodextrin moiety can encapsulate molecules. Herein, β-cyclodextrin (β-CD)-conjugated chitosan (CD-CHI) for loading and sustained-release of low-molecular-weight hydrophobic drugs was synthesized, and polysaccharide composite films containing β-CD units were prepared from polyion complexes consisting of chondroitin sulfate C and CD-CHI by hot press techniques. β-CD units of the obtained CD-CHI were modified by 9.2% of the amino groups in CHI units. The synthesized CD-CHI was used as a raw material for polysaccharide composite films. The mechanical strength and swelling ratio of the obtained films were comparable to those

SUBMITTER: Sagawa T 

PROVIDER: S-EPMC12643134 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature