Associations of cardiovascular health and social determinants of health with the risks of all-cause and cause-specific mortality.

ABSTRACT:

Background

While cardiovascular health (CVH) and social determinants of health (SDoH) are independently associated with mortality, their combined effects on mortality remain unclear. The study aimed to examine the mediating, interacting, and combined effects of CVH and SDoH on mortality risks.

Methods

We analyzed data from 20,096 adults in the National Health and Nutrition Examination Survey 2007-2018. CVH was assessed using the Life's Essential 8 (LE8) score and categorized into low, moderate, or high. Cumulative unfavorable SDoH burden was assessed and divided into low and high burdens of unfavorable SDoH. Multivariate Cox regression models were used to analyze the combined associations of SDoH and CVH with mortality. Mediation analysis was used to analyze the mediating ro

SUBMITTER: Pu B 

PROVIDER: S-EPMC12643303 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature